Animal models are crucial in the understanding of disease, the underlying pathways and the gene targets that play a role. One tool that has shown great value is the knockout mouse model.
The number of KO mouse models has increased massively since the first one in 1989, and mice models have been used successfully in increasing our understanding of diseases as varied as different cancers, diabetes, obesity, blindness, Huntington's disease, aggressive behaviour, and even drug addiction.
Understanding the landscape of KO mouse models for any particular disease area is important, and curated databases (e.g. IMPC or MGI) provide valuable data, but keeping track of new KO mouse models published in the scientific literature is challenging.
Peng Zhang, Senior Staff Scientist at Regeneron Pharmaceuticals, uses Linguamatics I2E to tackle this challenge, and he presented on “Text Mining for Knockout Mice and Phenotypes” earlier this year.