Posts from August 2018

There surely can’t be anyone in the pharma industry who hasn’t heard the story of thalidomide. The disaster that followed the release onto the market of thalidomide in 1959 triggered a wave of regulatory changes to ensure reliable evidence of drug safety, efficacy and chemical purity, before a new drug is released onto the market. 

While failure of clinical efficacy is the major cause of drug attrition, a poor safety profile is also a major factor in failure of drugs in development, at all stages from initial lead candidate through preclinical and clinical development to post-marketing surveillance. In order to ensure the safety of drugs on the market, rigorous testing is carried out throughout the pipeline, and can be categorised into preclinical safety/toxicology in animal models, clinical safety in human subjects, and then post-market pharmacovigilance, to look for safety signals across a wide patient population (see schematic below).

At every stage, critical data is being both generated and sought from unstructured text – from internal safety reports, scientific literature, individual case safety reports, clinical investigator brochures, patient forum, social media, conference abstracts. Intelligent search across these hundreds of thousands of pages can provide the information for key decision support. Many of our customers are using the power of Linguamatics I2E’s Natural Language Processing (NLP) solution to transform the unstructured text into actionable structured data that can be rapidly visualized and analyzed, at every stage through the safety lifecycle of a drug.


Our latest version of I2E includes improvements that make it easier to integrate the tool into your organization and process your internal documents, as well as the usual usability enhancements and under-the-hood modifications.

I2E 5.3.1 supports Single Sign-On (SSO) by connecting with Federated Authenticated Systems such as ADFS and Shibboleth. This means that you can be authenticated in one system and then seamlessly log into the I2E client without prompting for your credentials. If you are not already logged in via another system, I2E will initiate the login process via a redirect to a special web page.

We’ve improved the hit highlighting in our Excel results format (figure 1): terms from your search use the same colors for each column in your results and the colors are consistent across the I2E Query Editor, HTML results and highlighted cache documents.

Excel results show color-coded terms in the Hit column

Figure 1. Excel results show color-coded terms in the Hit column

A good example of recent continual improvement in I2E is the Class Chooser. In recent releases, we have increased search speed, added as-you-type class suggestions and, in I2E 5.3.1, we’ve added additional information for each class match to show which Ontology the term is from (figure 2). This helps to quickly review your results to get to your correct match(es), particularly when you’re using a term that could occur in different ontologies.