Over the past few months there have been several publications which have used Linguamatics I2E to extract key information to provide value in a variety of different projects. We are constantly amazed by the inventiveness of our users, applying text analytics across the bench to bedside continuum; and these different publications are no exceptions. Using the natural language processing power of I2E, researchers are able to answer their questions rapidly and extract the results they need, with high precision and good recall; compared to more standard keyword search, which returns a document set that they then need to read.
Let’s start with Hornbeck et al., “PhosphoSitePlus, 2014: mutations, PTMs and recalibrations”. PhosphoSitePlus is an online systems biology resource for the study of protein post-translational modifications (PTMs) including phosphorylation, ubiquitination, acetylation and methylation. It’s provided by Cell Signaling Technology who have been users of I2E for several years. In the paper, they describe the value from integrating data on protein modifications from high-throughput mass spectrometry studies, with high-quality data from manual curation of published low-throughput (LTP) scientific literature.