Publications

The role of chronic toxicology studies in revealing new toxicities

Galijatovic-Idrizbegovic A, Miller JE, Cornell WD, Butler JA, Wollenberg GK, Sistare FD, DeGeorge JJ.

Regul Toxicol Pharmacol. 2016 Oct; pii: S0273-2300(16)30299-9

PMID: 27769827

http://www.sciencedirect.com/science/article/pii/S0273230016302999

Abstract

Chronic (>3 months) preclinical toxicology studies are conducted to support the safe conduct of clinical trials exceeding 3 months in duration.


Reflection of successful anticancer drug development processes in the literature

Heinemann F, Huber T, Meisel C, Bundschus M, Leser U.

Drug Discov Today. 2016 Nov 16

PMID: 27443674 

http://www.ncbi.nlm.nih.gov/pubmed/27443674


Use of data mining at the Food and Drug Administration

Duggirala HJ, Tonning JM, Smith E, Bright RA, Baker JD, Ball R, Bell C, Bright-Ponte SJ, Botsis T, Bouri K, Boyer M, Burkhart K, Condrey GS, Chen JJ, Chirtel S, Filice RW, Francis H, Jiang H, Levine J, Martin D, Oladipo T, O'Neill R, Palmer LA, Paredes A, Rochester G, Sholtes D, Szarfman A, Wong HL, Xu Z, Kass-Hout T.

J Am Med Inform Assoc. 2016 Mar;23(2):428-34

PMID:26209436
http://jamia.oxfordjournals.org/content/23/2/428


Making sense of big data in health research: Towards an EU action plan

Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G

Genome Med. 2016 Jun 23;8(1):71

PMID:27338147

PMC ID: PMC4919856


Application of automated natural language processing (NLP) workflow to enable a federated search of external biomedical content in drug discovery development

McEntire R, Szalkowski D, Butler J, Kuo MS, Chang M, Chang M, Freeman D, McQuay S, Patel J, McGlashen M, Cornell WD, Xu JJ.

Drug Discov Today. 2016 May; 21(5):826-35

PMID: 26979546

http://www.sciencedirect.com/science/article/pii/S1359644616300757