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Real-World Data for Commercial Pharmaceutical Product Insights

Real-World Data for Commercial Pharmaceutical Product Insights

When people think about real-world evidence, they generally think about using these data to address questions around drug effectiveness, or population level safety effects. But there are many applications that “real-world data” can address. If you think of real-world data as any type of information gathered about drugs in non-trial settings, a whole world of possibilities opens up:

  • Social media data can be used to understand how well packaging and formulations are working.
  • Customer call feeds can be analyzed for trends in drug switching, off-label use, or contra-indicated medications among concomitant drugs.
  • Full text literature can be mined for information about epidemiology, disease prevalence, and more.

Text Mining transforms Real-World Data to Real-World Evidence

Many of these real-world sources have unstructured text fields, and this is where text analytics, and Natural Language Processing (NLP), can fit in. At Linguamatics, we have customers who are using text analytics to get actionable insight from real-world data – and finding valuable intelligence that can inform commercial business strategies.

In this blog, we will be looking at two different Linguamatics customer use cases, where text mining has been used to transform real-world data to real-world evidence.

Use Case 1: Evidence Landscape from Literature for Drug Economics

Understanding the potential for market access is essential for all pharma companies, and information to characterize the burden of disease and local standard of care in different countries across the globe is critical for any new drug launch. Companies need an assessment of the landscape of epidemiological data, health economics and outcomes information, in order to inform the optimal commercial strategy.

Valuable data is published every month in scientific journals, abstracts, and conferences. One of Linguamatics top 10 pharma customers decided to utilize text mining to extract, normalize, and visualize these data. They can then use this structured data to generate a comprehensive understanding of the available evidence and thus establish the market “gaps” that they could address. Focusing on a particular therapeutic area of immunological diseases, the organization was able to develop precise searches with increased recall across these different data sources, including full text literature.

Linguamatics I2E enables the use of ontologies to improve disease coverage, and incorporate domain knowledge to increase the identification of particular geographical regions (for example, enabling the use of the adjectival form of the country e.g. French as well as France, and cities e.g. Paris, Toulouse). I2E also extracts and normalizes numbers, which is useful to standardize epidemiological reports for incidence and prevalence of disease. Searching within full text papers can be noisy, and I2E allows search to be specific, and exclude certain regions from a search, such as the references.

I2E can provide the starting point for efficiently performing evidence based systematic reviews over very large sets of scientific literature, enabling researchers to answer questions around commercial business decisions.

Use Case 2: Gaining Insights from Medical Science Liaison Professionals

Conversations between medical science liaison (MSL) professionals and patients or healthcare professionals (HCPs) can lead to valuable insights. The role of the MSL is to ensure the effective use, and success, of a pharmaceutical company’s drug. MSLs act as the therapy area experts for internal colleagues, and also maintain good relationships with external experts, such as leading physicians, to educate and inform on new drugs and therapeutics.

Top pharma company Novo Nordisk use text mining to gain clinical insights from MSL interactions with HCPs. These interactions may be broad ranging, covering topics such as safety and efficacy, dosing, cost, special populations, indication, comparisons, competitor products, etc. MSLs may use approved slide decks, package inserts (PIs), factsheets, studies or publications to answer HCP questions. Linguamatics text mining platform is used to structure these source files with custom ontologies (e.g. for material types, product, disease terminology variation, topics).

Clinical insights from real world data using I2E text mining

Thierry Breyette, Novo Nordisk, presented at Linguamatics Text Mining Summit 2016 on “Generating actionable insights from real-world data”. The figure shows a map of where particular topics are discussed, and what materials are used.

This analysis enables Novo Nordisk to better address what support healthcare professionals may need in their interactions with patients, insurance providers, and other clinicians and enable Novo Nordisk to invest in resource development appropriately.

Interested in learning more about using I2E for mining full text literature and other real-world data applications? Keep exploring:

Or simply get in touch for more information:

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